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Growth Hormone in Fibromyalgia

 
 

 

 
  There is evidence that about one third of fibromyalgia patients have adult growth hormone (GH) deficiency. Although this is not thought to be the "cause" of fibromyalgia, it does represent a secondary abnormality, like insomnia, thyroid deficiency and depression, that can adversely impact the quality of life of patients.

Here are some of the major clinical features of adult growth hormone deficiency; many of these symptoms are present in fibromyalgia patients. But note that widespread pain is not a recorded feature of GH deficiency.

 

Clinical features of adult GH deficiency

 

Improved by GH replacement

 

Increased abdominal fat

Yes

Reduced muscle mass and strength

Yes

Reduced cardiac capacity

Yes

Reduced  blood volume

Yes

Easy fatiguability Yes

Cold intolerance

Probably

Impaired exercise capacity

Yes

Thin, dry skin

Yes

Reduced sweating

Yes

Reduced bone mineral density

Yes (delayed effect after 1 year)

Psychosocial dysfunction

Yes

Atherogenic lipid profile¤ 

Probably

Increased atherosclerosis

Not known

Reduced life expectancy

Not known

 

 

Over the next year researchers at OHSU will provide reviews and the results of research efforts that are relevant to GH abnormalities in fibromyalgia.

 Basic facts about GH and its secretion (highly technical)

Adult GH deficiency

OHSU research on an abnormal GH response to exercise and its potential treatment

 

 

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